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Polyethylene Pyrrolidone (PVP) is a water-soluble polyamide. The commercially available PvP is divided into four viscosity grades according to K value (fikentscher K value): K-15, K-30, K-60, K-90, the number of which is 10000 and 40000,160000 and 360000, respectively, relative to molecular mass.
K Value or relative molecular mass is one of the important factors that determine the various properties of PvP. Polyethylene Pyrrolidone (PVP) is soluble in water, chlorine-containing solvents, ethanol, amines, nitro alkanes and low molecular fatty acids, soluble with most inorganic salts and a variety of resins, insoluble in acetone, ether and so on. Polyethylene Pyrrolidone (PVP) for dripping pill matrix is odorless, tasteless, white to yellowish waxy solids with a relative density of 1.062,5% aqueous solution with a ph value of 3~7 and polyethylene pyrrolidone with Humidification. Good thermal stability, can be dissolved in a variety of organic solvents, high melting point. The addition of certain natural or synthetic polymers or organic compounds can effectively regulate the moisture and softness of PVP. Polyethylene Pyrrolidone is not easy to undergo chemical reactions, stored under normal conditions, dry PvP is very stable.
PvP has excellent physiological inertia and biocompatibility, no irritation to the skin, eyes, no allergic reaction, non-toxic. Due to the effect of hydrogen bonding or complexation, the viscosity of polyethylene pyrrolidone (PVP) increased and inhibited the formation and growth of drug nuclei, making the drug into an unshaped state. The dissolution and bioavailability of refractory drugs can be improved by dropping pills based on polyethylene pyrrolidone (PVP). Generally speaking, the larger the amount of PvP, the greater the dissolution and solubility of the drug in the medium. The dissolution of the PvP (K30) Solid dispersion of Susana, a minimally soluble drug, was studied. The amount of PVP (K30) increased, and the dissolution speed and dissolution efficiency of the drugs in the solid dispersion increased. Teresa and others studied the dissolution of the refractory drug, the PVP solid dispersion of fluorine guilizine, and found that the higher the PvP content, the more significant the dissolution increased. IR showed that fluorine guilizine had no chemical effect with PVP. However, there are exceptions, some drugs and PvP in a certain proportion of dissolution effect is the best.
Tantishaiyakul and other studies found that when Imidacloprid: PvP was 1:5 and 1:6, the solid dispersion had the largest dissolution and was 40 times times higher in 5min than a single drug. Polyethylene Pyrrolidone (PVP) can also be dissolved in molten other drop pill substrates, such as polyethylene glycol (PEG), Polyoxyethylene single stearate (S-40), mooring Poloxam (poloxamer), stearic acid, single stearic acid glycerides, etc., made into a composite matrix.
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