The main harm of formaldehyde is the stimulation to skin mucous membrane.When formaldehyde achieves certain concentration indoors, the person has unwell feeling.Formaldehyde concentration greater than 0.08 mg/m cubed can cause red eyes, itchy eyes, sore throat, hoarse voice, sneezing, chest tightness, wheezing, dermatitis, etc.The formaldehyde content of newly decorated room is higher, it is the main inducement of many diseases.
LD guanxi stress: 800mg
(rat meridional), 2700mg
(rabbit transcutaneous);LC dobdr. : 590mg/m cubed (inhaled by rats);
People inhaled 60 ~ 120mg/m cubed and suffered from bronchitis and serious lung damage.
Human inhaled 12 ~ 24mg/m cubed, nose, pharyngeal mucosa burns seriously, tears, cough;10 ~ 20mL of human menstrual mouth, lethal.
High formaldehyde concentration can cause acute poisoning, which is manifested as sore throat, dyspnea, pulmonary edema, allergic purpura, allergic dermatitis, elevated liver transaminase, jaundice, etc.
Subacute and chronic toxicity:
Rats were inhaled at 50-70mg/m cubed for 1 hour/day, 3 days/week and 35 weeks.
Inhalation of 20-70mg/m cubed for a long time will cause loss of appetite, weight loss, weakness, headache and insomnia.
Long-term inhalation of 12mg/m cubed can cause drowsiness, weakness, headache, finger tremors and decreased vision.
Formaldehyde has pungent smell, can be smelled at low concentration, the olfactory threshold of human to formaldehyde is usually 0.06 to 0.07mg/m cubed.However, there are large individual differences. Some people can reach 2.66mg/m cubed.Long-term and low-concentration exposure to formaldehyde may cause headache, dizziness, fatigue, sensory disturbance, and decreased immunity, and may cause drowsiness, memory loss or neurasthenia, and mental depression.Chronic poisoning is also a great danger to the respiratory system. Long-term exposure to formaldehyde can cause respiratory dysfunction and liver toxicity, which are shown as liver cell damage and abnormal liver radiation energy.
Microbiological mutation: salmonella typhimurium 4mg/L.Mammalian somatic cell mutation: human lymphocytes at 130 MB /L.Sister chromosome exchange: human lymphocyte 37pph.
Since 2010, formaldehyde has been found to cause genetic mutations, chromosomal damage and eight-fold breakage in mammalian nuclei.The combination of formaldehyde with other polycyclic aromatic hydrocarbons, such as benzopyrene, can increase toxicity.
IARC's carcinogenic comments were once "animal positive;Humans are unclear ", and further studies confirmed it as a class 1 carcinogen in 2006.
Rats exposed to 15 grams of formaldehyde per cubic meter for 11 months were found to cause nose cancer.A new study released on May 12, 2009 by the U.S. -private domestic cancer institute shows that workers exposed to formaldehyde in chemical plants are far more likely to die from cancers such as blood cancer and lymphoma than workers exposed to less formaldehyde.Researchers surveyed 25,000 factory workers who produced formaldehyde and formaldehyde resin, and found that the workers with the highest exposure to formaldehyde had a 37 percent higher mortality rate than those with the lowest exposure.Long-term exposure to formaldehyde increased the risk of specific cancers such as Hodgkin's lymphoma, multiple myeloma and myeloid leukemia, the researchers said.
The lowest oral toxic dose (TDL0) in rats: 200mg
(1 day, male), which had an effect on sperm survival.Minimal toxic concentration (TCL0) was inhaled in rats: 12ug/m cubed for 24 hours (1-22 days), causing biochemical and metabolic changes in newborn mice.